Pantoprazole is a proton pump inhibitor which has recently herd its clinica
l license extended to include maintenance therapy for the treatment of refl
ux oesophagitis, Helicobacter pylori eradication and short-term intravenous
administration, This article reviews the history of gastric gastric acid s
ecretion and examines the role of proton pump inhibitors, particularly pant
oprazole, in the treatment of acid-related disorders.