Synthesis of some thiazolidinones and 5-oxo-immidazolines as biologically potent agents

Citation
Ah. Bhatt et al., Synthesis of some thiazolidinones and 5-oxo-immidazolines as biologically potent agents, I J CHEM B, 38(5), 1999, pp. 628-631
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
5
Year of publication
1999
Pages
628 - 631
Database
ISI
SICI code
0376-4699(199905)38:5<628:SOSTA5>2.0.ZU;2-N
Abstract
4-Aminobenzophenone 1 on condensation with different araldehydes yield schi ffs bases 2a-o which on cyclization with mercapto acetic acid afford the co rresponding 4-(5'H-2'aryl-4'-thiazolidinon-3'-yl)-benzophenones 3a-o. While cyclocandensation of 1 with various azlactones yield 4-(4'-arylidene-2'-ph enyl-5'-oxa-imidazolin-1'-yl)benzophenones 4a-m. The structure of the compo unds have been confirmed from elemental analysis, IR, H-1 NMR and mass spec tral data. All the compounds have been evaluated in vitro for antimicrobial and antimycobacterial activities.