Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB/c mice infected with Leishmania major

Lesion size, cellular infiltration, and tissue parasitism in the footpads o f BALB/c mice infected with Leishmania major were all dramatically inhibite d during acute but not chronic infection with Toxoplasma gondii. Similarly, acute but not chronic toxoplasmosis at the time of infection with L. major had a strong inhibitory effect on development of acquired immune responses mediated by Th2 lymphocytes. In contrast, no major changes in Leishmania-s pecific Th1-mediated responses were observed in mice coinfected with T. gon dii.