Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB/c mice infected with Leishmania major
Hc. Santiago et al., Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB/c mice infected with Leishmania major, INFEC IMMUN, 67(9), 1999, pp. 4939-4944
Lesion size, cellular infiltration, and tissue parasitism in the footpads o
f BALB/c mice infected with Leishmania major were all dramatically inhibite
d during acute but not chronic infection with Toxoplasma gondii. Similarly,
acute but not chronic toxoplasmosis at the time of infection with L. major
had a strong inhibitory effect on development of acquired immune responses
mediated by Th2 lymphocytes. In contrast, no major changes in Leishmania-s
pecific Th1-mediated responses were observed in mice coinfected with T. gon
dii.