Prognostic factors relating to survival in uterine endometrioid carcinoma

Objective: Epidemiologic and clinicohistopathologic prognostic factors of u terine endometrioid carcinomas were analyzed. The association of estrogen r elated factors, focused on adenomyosis in the prognosis of endometrioid car cinomas was also examined. Methods: Risk factors of surgically treated 286 patients with endometrioid carcinoma (Stage I-III) were statistically analy zed. Results: Overall a recurrence-free 5-year survival rate was 81% (Stage I, 94%, Stage II, 71% and Stage III, 40%). Significant prognostic factors were lymph node metastases (P = 0.0035) and serosal/parametrial invasion (P = 0.014) by multivariate analysis. Endometrioid carcinomas with co-existin g adenomyosis tend to be associated with endometrial hyperplasia (P = 0.04, Fisher's exact test), diagnosed in less invasive status (myometrial invasi on, P = 0.004 and serosal/parametrial invasion, P = 0.006) and therefore ha ve a favorable prognosis (P = 0.01, log rank test). Conclusions: A favorabl e prognosis of endometrioid carcinomas with co-existing estrogen related fa ctors (adenomyosis and endometrial hyperplasia) was suggested. (C) 1999 Int ernational Federation of Gynecology and Obstetrics.