Glycopeptide tolerance in bacteria causing endocarditis

Citation
Jd. Perry et al., Glycopeptide tolerance in bacteria causing endocarditis, J ANTIMICRO, 44(1), 1999, pp. 121-124
Citations number
10
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
44
Issue
1
Year of publication
1999
Pages
121 - 124
Database
ISI
SICI code
Abstract
Glycopeptides have been recommended as therapy for endocarditis. MICs and M BCs of vancomycin and teicoplanin were compared for 100 isolates from patie nts with proven bacterial endocarditis. MICs were generally lower for teico planin and tolerance to both agents was common. Almost all isolates of ente rococci were tolerant to both glycopeptides. Among the streptococci, 78% we re tolerant to teicoplanin and 57% to vancomycin. Similar findings were dem onstrated for staphylococci. Although isolates appear sensitive to glycopep tides, bactericidal activity cannot always be predicted. If a glycopeptide is indicated for treatment of endocarditis, combination therapy with a suit able aminoglycoside should be considered unless MBC testing can be performe d.