Evidence of the existence of 2 : 1 guest-host complexes between diclofenacand cyclodextrins in D2O solutions. A H-1 and C-13 NMR study on diclofenac/beta-cyclodextrin and diclofenac/2-hydroxypropyl-beta-cyclodextrin systems

Authors
Mucci, A Schenetti, L Vandelli, MA Ruozi, B Forni, F
Citation
A. Mucci et al., Evidence of the existence of 2 : 1 guest-host complexes between diclofenacand cyclodextrins in D2O solutions. A H-1 and C-13 NMR study on diclofenac/beta-cyclodextrin and diclofenac/2-hydroxypropyl-beta-cyclodextrin systems, J CHEM R-S, (7), 1999, pp. 414-415A
Citations number
28
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
7
Year of publication
1999
Pages
414 - 415A
Database
ISI
SICI code
0308-2342(199907):7<414:EOTEO2>2.0.ZU;2-F
Abstract
The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, be ta-cyclodextrin (beta CD) and 2-hydroxypropyl-beta-cyclodextrin (HP beta CD ), studied in D2O solution with different NMR techniques (H-1, C-13 NMR, RO ESY experiments, NMR titrations), shows the existence of multiple equilibri a involving 1:1 and 2:1 guest-host complexes.