Kb. Waites et al., Detection of Chlamydia trachomatis endocervical infections by ligase chainreaction versus ACCESS Chlamydia antigen assay, J CLIN MICR, 37(9), 1999, pp. 3072-3073
Ligase chain reaction (LCR) was compared with ACCESS immunoassay for detect
ion of chlamydial infections in females. Despite efforts to improve ACCESS
performance by evaluation of specimens that were in the test performance "g
rey zone," LCR remained more sensitive and was less expensive to perform. A
CCESS had a sensitivity of 83.9%, a specificity of 99.7%, a positive predic
tive value of 96.3%, and a negative predictive value of 98.5%.