SERIAL BACKCROSS MAPPING OF MULTIPLE LOCI ASSOCIATED WITH RESISTANCE TO LEISHMANIA-MAJOR IN MICE

Citation
Am. Beebe et al., SERIAL BACKCROSS MAPPING OF MULTIPLE LOCI ASSOCIATED WITH RESISTANCE TO LEISHMANIA-MAJOR IN MICE, Immunity, 6(5), 1997, pp. 551-557
Citations number
26
Categorie Soggetti
Immunology
Journal title
ISSN journal
10747613
Volume
6
Issue
5
Year of publication
1997
Pages
551 - 557
Database
ISI
SICI code
1074-7613(1997)6:5<551:SBMOML>2.0.ZU;2-J
Abstract
Resistance or susceptibility of inbred mouse strains to the parasite L eishmania major correlates with CD4(+) T cell responses of the Th1 or Th2 subsets, respectively. To evaluate the genetic basis for this diff erence, resistant B10.D2 mice were backcrossed onto susceptible BALB/c mice for five generations with selection for resistance. Candidate re sistance loci were identified by high frequency of heterozygosity in r esistant N5 backcross mice. Loci on chromosomes 6, 7, 10, 11, 15, and 16 were associated with resistance, demonstrating the multigenic natur e of this phenotype. The presence of all six loci was not necessary to confer resistance and no single locus was required. Rather, a variety of combinations of these loci may be capable of interacting to confer resistance.