Chloride and ethyl ester morpholine thiourea derivatives and their Ni(II) complexes. Crystal and molecular structures of the thiourea derivative L-leucine methyl ester and its complexes with Cu(II) and Pt(II). Growth of the pathogenic fungus Botrytis cinerea

We have synthesized a series of ligands (1, 3, 4, 6 and 7) and some of thei r complexes with Ni(II), Cu(II) and Pt(II) (2, 5, 8 and 9). These compounds were studied and characterized by elemental analysis, IR and W-Vis spectra , conductivity measurements in solution, FAB(+)/MS, H-1 and C-13 NMR, ESR, etc. Compound 7 crystallized in the orthorhombic space group P2(1)2(1)2(1), with Z=4. Unit cell parameters were as follows: a = 21.307(2) Angstrom, al pha = 90 degrees, b = 12.498(1) Angstrom, beta = 90 degrees, c = 7.7232(4) Angstrom, gamma = 90 degrees. For seven of these compounds, the antifungal activity of a major pathogen responsible for important crop damage was stud ied. In general, inhibition by the ligands was higher than that of the comp lexes. When the thiourea was linked to some diethyl groups, the compounds s howed higher antifungal activity than the morpholine groups. Compound 3 ach ieved total inhibition (100%). (C) 1999 Elsevier Science Inc. All rights re served.