Clinical investigation of atypical adenomatous hyperplasia of the lung

The clinicopathologic characteristics of atypical adenomatous hyperplasia ( AAH) remain unclear. A total of 137 patients underwent resection for adenoc arcinoma of the lung at our institution. Examination of resected lung tissu e showed that in addition to adenocarcinoma AAH was present in 26 cases and was not present in 111 cases. All nonsmokers with AAH (n = 13) had earlier -stage disease (stage IA, IB, IIA, and IIB) and no history of respiratory d isease. Among patients with stage IA disease, the relapse-free and overall survival curves for those with AAH (n = 14) tended to be better than for th ose without AAH (n = 40), but the difference was not statistically signific ant (P = 0.056 and 0.087, respectively). Concurrent presence of AAH may be a favorable prognostic indicator in patients with stage IA adenocarcinoma. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.