Pathological homeostasis: its meaning, its inferences

The notion of 'pathological homeostasis' (PH) allows a better understanding of the escape phenomena to the effects of a therapy, as suggested by exper imental researches. This concept refers to mechanisms we already know as de sensitization, mutation, etc. Moreover, it focuses on the following possibi lity: in a couple of antagonistic agents, the already prevalent one will in crease even more so that it could cancel the therapeutic effect of the admi nistered opposite agent. PH is also defined as a change in the norms of the cell regulation or of the great systems of regulation in the body. In orde r to neutralize this occurrence, the PH notion may open up on new experimen tal studies and therapeutical strategies.