The first examination of the use of active matrix flat-panel arrays for dos
imetry in radiotherapy is reported. Such arrays are under widespread develo
pment for diagnostic and radiotherapy imaging. In the current study, an arr
ay consisting of 512X512 pixels with a pixel pitch of 508 mu m giving an ar
ea of 26X26 cm(2) has been used. Each pixel consists of a light sensitive a
morphous silicon (a-Si:H) photodiode coupled to an a-Si:H thin-film transis
tor. Data was obtained from the array using a dedicated electronics system
allowing real-time data acquisition. In order to examine the potential of s
uch arrays as quality assurance devices for radiotherapy beams, field profi
le data at photon energies of 6 and 15 MV were obtained as a function of fi
eld size and thickness of overlying absorbing material (solid water). Two d
etection configurations using the array were considered: a configuration (s
imilar to the imaging configuration) in which an overlying phosphor screen
is used to convert incident radiation to visible light photons which are de
tected by the photodiodes; and a configuration without the screen where rad
iation is directly sensed by the photodiodes. Compared to relative dosimetr
y data obtained with an ion chamber, data taken using the former configurat
ion exhibited significant differences whereas data obtained using the latte
r configuration was generally found to be in close agreement. Basic signal
properties, which are pertinent to dosimetry, have been investigated throug
h measurements of individual pixel response for fluoroscopic and radiograph
ic array operation. For signal levels acquired within the first 25% of pixe
l charge capacity, the degree of linear response with dose was found to be
better than 99%. The independence of signal on dose rate was demonstrated b
y means of stability of pixel response over the range of dose rates allowed
by the radiation source (80-400 MU/min). Finally, excellent long-term stab
ility in pixel response, extending over a 2 month period, was observed. (C)
1999 American Association of Physicists in Medicine. [S0094-2405(99)02308-
1].