Adenylate kinase from human placenta: Phosphorylation of modified nucleoside 5 '-phosphonates

Authors
Skoblov, YS Frank-Kamenetskaya, MD Chernov, DN
Citation
Ys. Skoblov et al., Adenylate kinase from human placenta: Phosphorylation of modified nucleoside 5 '-phosphonates, MOL BIOL, 33(4), 1999, pp. 485-490
Citations number
25
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
33
Issue
4
Year of publication
1999
Pages
485 - 490
Database
ISI
SICI code
0026-8933(199907/08)33:4<485:AKFHPP>2.0.ZU;2-F
Abstract
Substrate and inhibitory properties of modified monophosphoric nucleoside d erivatives toward adenylate kinase from human placenta were studied. Some H -phosphonates and fluorophosphates demonstrated inhibitory properties, deox ycompounds being considerably different from analogous ribo- and dideoxyrib ocompounds. 3'-Azido-3'-deoxythymidine and its phosphorus-containing deriva tives showed neither substrate nor inhibitory properties.