Calcium-containing endosomes at oculomotor terminals in animal models of ALS

Citation
L. Siklos et al., Calcium-containing endosomes at oculomotor terminals in animal models of ALS, NEUROREPORT, 10(12), 1999, pp. 2539-2545
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
10
Issue
12
Year of publication
1999
Pages
2539 - 2545
Database
ISI
SICI code
0959-4965(19990820)10:12<2539:CEAOTI>2.0.ZU;2-J
Abstract
ALTERED calcium homeostasis has been demonstrated in human spinal cord moto r axon terminals of ALS patients, in spinal motor neurons of mutant SOD tra nsgenic mice and following injection of ALS immunoglobulins. In all three p aradigms oculomotor neurons are relatively spared. To explore mechanisms of selective resistance, we applied similar calcium localization techniques t o terminals of oculomotor neurons in the two animal models. In both cases l arge vacuoles, which connect with the extracellular space, accumulated the majority of intracellular calcium, while terminals of vulnerable neurons (e .g. innervating interosseus muscle), which possess no such vacuoles, displa yed evenly distributed calcium. These relatively unique membrane enveloped structures may permit neurons to control their cytoplasmic Ca2+ concentrati on and contribute to selective resistance. NeuroReport 10:2539-2545 (C) 199 9 Lippincott Williams & Wilkins.