Cooccurrence of reduced expression of alpha-catenin and overexpression of p53 is a predictor of lymph node metastasis in early gastric cancer

Background and Objectives: Even though the pathological background contribu tes to lymph node metastasis, the biological characteristics of tumors have also gained wide attention. In this study, the expression of the cadherin- catenin complex and p53 was studied in early gastric cancer. Their correlat ion with lymph node metastasis and the predictability of lymph node metasta ses, by combining these factors, were also discussed. Methods: One hundred and one specimens obtained from surgery were studied by immunohistochemistr y using monoclonal anti-E-cadherin, anti-alpha-catenin and anti-p53 antibod ies. Results: Expression of E-cadherin and alpha-catenin was reduced in 50. 5 and 64.4%, respectively, p53 protein staining was positive in 29.7%, Ther e was a significant correlation between E-cadherin and alpha-catenin expres sion, but no correlation was found between p53 expression and E-cadherin or alpha-catenin expression. A reduction in alpha-catenin expression and p53 overexpression correlated to lymph node metastases, respectively. Multivari ate analysis showed that cooccurrence of reduced expression of alpha-cateni n and overexpression of p53 was an independent factor indicating lymph node metastases. Conclusion: A study of both alpha-catenin and p53 expression m ay be helpful to predict lymph node metastases in early gastric cancer.