Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects

Traditional lipophilicity parameters (log P and log D) are well-known physi co-chemical descriptors largely used in QSAR studies. Besides their numeric al value, log P data contain a variety of information about inter- and intr amolecular forces affecting partitioning and its related biological phenome na. The deconvolution of information from log P can be accessed only by ade quate interpretative tools, such as new lipophilic-combined descriptors, of which features and some applications are presented in this review.