A. Bijev et al., Introduction of a pyrrole cycle in cephalosporine structures as approach in the search for new beta-lactame antibiotics, PHARMAZIE, 54(8), 1999, pp. 567-570
12 New cephalosporines containing a pyrrole cycle in the N-acyl chain have
been synthesized based on N-acylation of 7-ACA or of its 3'-analogues via t
he mixed anhydrides of substituted pyrrole carboxylic acids, and following
two types of procedure. Confirming H-1 NMR and IR data are represented. The
preliminary microbiological tests in vitro show significant antibacterial
activity in some cases compared with that of cefalexin. Some common structu
re-activity relationships have been observed.