Response of blood platelets to resveratrol

The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found i n grapes and wine, has been reported to have a variety of anti-inflammatory , anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood plat elets to collagen, as well as on thrombin-induced platelet aggregation and malonyldialdehyde (MDA) production in vitro. Pretreatment of platelets with resveratrol (50 mu g/ml) inhibited their adhesion to collagen (by 32% in r esting platelets and by 57% in thrombin-activated platelets after 1 h of pr eincubation) and thrombin-induced platelet aggregation (by 59% after 30 min preincubation). Resveratrol also had an inhibitory effect on the generatio n of malonyldialdehyde (a marker of thromboxane A(2) synthesis) measured as thiobarbituric reactive substance in thrombin-activated platelets.