Energy-resolved mass spectrometry: a comparison of quadrupole cell and cone-voltage collision-induced dissociation

Collision-induced dissociation (CID) can be effected in the interface regio n between atmospheric pressure ionization sources and single quadrupole mas s analyzers. By varying the electric field in these cone-voltage CID experi ments energy-resolved mass spectra can be obtained leading to breakdown gra phs exploring the energy evolution of the fragmentation pathways. The break down graphs obtained from these cone-voltage CID studies are very comparabl e to those obtained by varying the collision energy in the quadrupole colli sion cell of a BEqQ mass spectrometer, The comparison has been made for the protonated peptides H-Leu-Gly-Gly-OH, H-Gly-Leu-Gly-OH, H-Gly-Giy-Leu-OH a nd Leu-enkephalin Copyright (C) 1999 John Whey & Sons, Ltd.