Morphea and localized scleroderma in children

Localized scleroderma refers to a diverse spectrum of disorders that involv e fibrosis of the skin. Children are more likely than adults to develop loc alized forms of scleroderma. This condition may have devastating effects on growth and develop ment such as limb asymmetry, flexion contractures, and psychological disability. The pathogenesis of localized scleroderma is unkn own but its possible relation to Borrelial infection is discussed. This art icle reviews associated laboratory and radiologic abnormalities, and discus ses implications for monitoring disease activity. There is no universally e ffective therapy for this idiopathic condition and therapy is limited. A ra tionale for treatment based on disease subtype and severity is provided. Co pyrights (C) 1999 by W.B. Saunders Company.