Recent re-evaluation of the natural course of chronic pancreatitis has sugg
ested that many patients do not experience pain alleviation with progressiv
e "burning out" of the organ. Thus, therapeutic nihilism is not warranted i
n chronic pancreatitis, especially because criteria to select those patient
s becoming eventually pain-free do not exist. Concurrently, many new therap
eutic options have emerged, such as endoscopic interventions combined with
extracorporeal shock wave lithotripsy and modern organ-sparing surgical pro
cedures. This article reviews the background and results of these modern su
rgical alternatives to classical drainage and resection procedures with spe
cial regard to duality of life, which turns out to be the crucial endpoint
for the patient.