COOPERATIVITY AND STABILITY IN A LANGEVIN MODEL OF PROTEINLIKE FOLDING

Authors
BERRIZ GF GUTIN AM SHAKHNOVICH EI
Citation
Gf. Berriz et al., COOPERATIVITY AND STABILITY IN A LANGEVIN MODEL OF PROTEINLIKE FOLDING, The Journal of chemical physics, 106(22), 1997, pp. 9276-9285
Citations number
30
Categorie Soggetti
Physics, Atomic, Molecular & Chemical
Journal title
The Journal of chemical physics → ACNP
ISSN journal
00219606
Volume
106
Issue
22
Year of publication
1997
Pages
9276 - 9285
Database
ISI
SICI code
0021-9606(1997)106:22<9276:CASIAL>2.0.ZU;2-W
Abstract
We present two simplified models of protein dynamics based on Langevin 's equation of motion in a viscous medium. We explore the effect of th e potential energy function's symmetry on the kinetics and thermodynam ics of simulated folding. We find that an isotropic potential energy f unction produces, at best, a modest degree of cooperativity. In contra st, a suitable anisotropic potential energy function delivers strong c ooperativity. (C) 1997 American Institute of Physics.