Four canine isolates of S. intermedius resistant to enrofloxacin were isola
ted amongst a total of 429 screened. Two of these were shown to exhibit res
istance also to marbofloxacin and ciprofloxacin. Whilst molecular studies h
ave shown the mechanism of resistance to these quinolone antibiotics to be
similar in a number of staphylococcal species, it was not possible to confi
rm this mechanism in Staphylococcus intermedius.