BREAST-CANCER AND PESTICIDES IN HAWAII - THE NEED FOR FURTHER STUDY

Only 30% of all breast cancer can be explained by known risk factors. Increases in breast cancer incidence rates in Hawaii over the past few decades cannot be attributed solely to improvements in screening and detection. Avoidable environmental factors may contribute to a proport ion of the unexplained cases. Emerging evidence on endocrine disruptio n suggests that environmental chemicals may play a role in the develop ment of breast cancer. Agricultural chemicals, including endocrine dis rupters, have been used intensively in Hawaii's island ecosystem over the past 40 years leaching into groundwater, and leading to unusually widespread occupational and general population exposures. This paper d iscusses breast cancer patterns in Hawaii in the context of documented episodes of exposure to two endocrine-disrupting chemicals, chlordane /heptachlor and 1,2-dibromo-3-chloropropane (DBCP), at levels that som etimes exceeded federal standards by several orders of magnitude. in l ight of this history, detailed geographic-based studies should be unde rtaken in Hawaii to elucidate the potential role of environmental fact ors in the development of breast cancer and other diseases.