The crystal structure of the title compound, C16H21Cl-N3S+. Br-. CH3OH, the
hydrobromide salt of (S)-8-Cl-TIBO (tivirapine), reveals a distorted boat-
sofa conformation for the diazepine ring, with the methyl group and the 3-m
ethylbut-2-enyl side chain in equatorial and axial positions, respectively.
The protonated N atom has the S configuration. A conformational analysis o
f (S)-8-Cl-TIBO shows the conformational flexibility of this HIV-1 inhibito
r.