A non-peptide angiotensin II receptor antagonist: 2-butyl-6-methyl-5-(1-oxopyrid-2-yl)-1-{[2 '-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl)-1H-imidazo[5,4-b]pyridine methanol solvate

The title compound, C30H28N8O . CH4O, is one of a series of imidazo[5,4-b]p yridine-based angiotensin II receptor antagonists showing high antihyperten sive activity. The overall conformation of the biphenyltetrazole moiety as well as its relative orientation with respect to the central fused ring is significantly different from those of related compounds, indicating that th is class of compounds has considerable conformational flexibility.