Fd. Rochon et L. Breau, (2S*,4S*,5R*)-4-methyl-2-[(5S*)-3-methyl-4,5-dihydroisoxazol-5-yl]-5-phenyl-3(toluene-4-sulfonyl) oxazolidine, ACT CRYST C, 55, 1999, pp. 1373-1375
The title compound, C21H24N2O4S, containing 2-isoxazoline and oxazolidine m
oieties, was studied in order to determine its relative configuration, whic
h could not be determined unambiguously by NMR techniques. The results have
shown that the substituents on the three C atoms of the oxazolidine cycle
are all on the same side of the ring, while the aromatic group of the tolue
ne-4-sulfonate substituent on the N atom is located on the opposite side. T
he 2-isoxazoline ring was found to have the 5'S* configuration.