2,3,4,5,6,7-hexahydro-9,10-dimethoxy-1,2-benzothiazonin-3-one 1,1-dioxide

The amide group in the nine-membered ring of the title compound, C13H17NO5S , has the trans conformation. The molecules are linked into infinite one-di mensional chains by bifurcated intermolecular N-H ... O hydrogen bonds invo lving the amide O atom and one of the sulfonyl O atoms of the same neighbou ring molecule. The compound was prepared by the Friedel-Crafts acylation of 1,2-dimethoxybenzene and glutaric acid anhydride, followed by reduction of the aryl ketone, esterification, chlorosulfonation, treatment with ammonia , saponification and cyclization of the corresponding 5-(2-sulfamoylphenyl) butanoic acid.