Terminal deletion of chromosome 10q at band 26.1: Follow-up in an adolescent male with high-output renal failure from congenital obstructive uropathy

We report on the clinical findings in an adolescent male with a de novo ter minal deletion of chromosome 10 del(10)(q26.1). This young man is one of th e oldest known patients reported with this condition. His condition is comp ared with that of 11 reported cases of de novo terminal deletion of 10q at band 26, Individuals with chromosome 10q26 deletion have some findings and medical complications in common, Our patient has chronic renal failure due to urinary tract obstruction from posterior urethral valves, Similar anomal ies have been reported in cases of 10q26 deletion, suggesting a careful ren al/urinary tract evaluation should be completed in individuals with this co ndition. (C) 1999 Wiley-Liss, Inc.