P. Franceschini et al., Bladder carcinoma in Costello syndrome: Report on a patient born to consanguineous parents and review, AM J MED G, 86(2), 1999, pp. 174-179
We report on a 12-year-old boy with Costello syndrome born to consanguineou
s (first cousins once removed) parents, supporting the hypothesis of recess
ive transmission of this syndrome. At age 11 years, the patient developed a
bladder carcinoma, a rare pediatric tumor not previously described in Cost
ello syndrome, This suggests that an increased risk of malignancy may be pa
rt of this condition. (C) 1999 Wiley-Liss, Inc.