Bladder carcinoma in Costello syndrome: Report on a patient born to consanguineous parents and review

Authors
Franceschini, P Licata, D Di Cara, G Guala, A Bianchi, M Ingrosso, G Franceschini, D
Citation
P. Franceschini et al., Bladder carcinoma in Costello syndrome: Report on a patient born to consanguineous parents and review, AM J MED G, 86(2), 1999, pp. 174-179
Citations number
26
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
01487299 → ACNP
Volume
86
Issue
2
Year of publication
1999
Pages
174 - 179
Database
ISI
SICI code
0148-7299(19990910)86:2<174:BCICSR>2.0.ZU;2-M
Abstract
We report on a 12-year-old boy with Costello syndrome born to consanguineou s (first cousins once removed) parents, supporting the hypothesis of recess ive transmission of this syndrome. At age 11 years, the patient developed a bladder carcinoma, a rare pediatric tumor not previously described in Cost ello syndrome, This suggests that an increased risk of malignancy may be pa rt of this condition. (C) 1999 Wiley-Liss, Inc.