Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?

OBJECTIVE and STUDY DESIGN: We report for the first time an inhibitory effe ct on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ t ube formation by C albicans, as well as budding (inhibition of cell divisio n) of strains of other Candida species (ie, C glabrata, C krusei, and C tro picalis). CONCLUSIONS: We hypothesize that the presence of these and possibly other b acterial amines produced by anaerobes in the vaginal flora and seen in bact erial vaginosis, as in the healthy gut, may explain why candidosis is rarel y seen in these instances.