Substance use disorders in high-risk adolescent offspring

Objective: To examine the risk for substance use disorders (SUD) in offspri ng of SUD parents who were not selected due to referral to SUD treatment ce nters. Method: The original sample was ascertained through two groups of in dex children: 140 ADHD probands and 120 non-ADHD comparison probands. These groups had 174 and 129 biological siblings and 279 and 240 parents, respec tively. Results: We found that: 1) parental SUD was associated with SUD and all SUD subtypes in the offspring; 2) parental alcohol use disorders were associated with alcohol use disorders in the offspring as well as co-occurr ing alcohol and drug use disorders but not drug use disorders alone in the offspring; and 3) drug use disorders in the parents were associated with dr ug use disorders but not alcohol use disorders in the offspring. Conclusion s: I;These findings suggest that alcoholism and drug abuse may breed true f rom parents to their offspring, but further work! with larger samples is ne eded to confirm this idea. Our findings also suggest a possible common diat hesis that is expressed as comorbid alcohol and drug use in the offspring o f alcoholic parents. If confirmed, these findings may be useful for the dev elopment of preventive and early intervention strategies for adolescents at high risk for SUD based on parental history of SUD.