Safe pulmonary resection after chemotherapy and high-dose thoracic radiation

Background. Pulmonary resection after high-dose thoracic irradiation is rep orted to be associated with a high morbidity and mortality, and has been co nsidered to be prohibitive. Methods. We report safe pulmonary resection in 19 consecutive patients rece iving neoadjuvant therapy that included greater than 59 Gy thoracic radiati on. The mean thoracic radiation dose was 61.8 Gy (range 59.5-66.5) and mean age was 52 years (range 36-72 years). Cell type was adenocarcinoma (6), sq uamous (7), and other non-small cell lung cancer (NSCLC) (6). Sixteen of 19 patients received concurrent chemotherapy. Median time from end of treatme nt to surgical resection was 89 days (range 22-258 days). Surgical resectio n included 13 lobectomies and six pneumonectomies (four right, two left). Results. A complete pathologic response was seen in 8 of 19 (42%) patients. Three patients required intraoperative transfusion of blood. Mean intensiv e care unit stay was 2.0 days (range 1-8 days), and mean length of stay (LO S) was 8.0 days (range 3-18 days). There were four postoperative complicati ons; one bronchopulmonary fistula, one subarachnoid-pleural fistula, and 2 patients with prolonged atelectasis. There was no incidence of acute respir atory distress syndrome (ARDS) or operative mortality. Conclusions. Pulmonary resection, including pneumonectomy, after chemothera py and high-dose thoracic radiation may be performed safely with a low rate of intraoperative and postoperative complications. (C) 1999 by The Society of Thoracic Surgeons.