This paper discusses the potential for time of year to influence the o
utcome of aquatic hazard assessments. Exposure of fish to contaminants
under winter conditions can cause them to develop Wi,ter Stress Syndr
ome (WSS). Substantial mortality can result, potentially changing year
-class strength and population structure of the affected species, and
altering community-level ecological interactions. Aquatic contaminants
should be evaluated in the context of seasonal metabolic changes that
normally occur in test organisms. WSS could be an important, but as y
et unquantified, cause of mortality in many circumstances. Wastewater
discharges may pose a greater toxic threat to fish during winter than
at other times of the year. A comprehensive protocol for aquatic hazar
d assessment should include testing for WSS.