Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica

Authors
Kwon, HC Lee, BG Kim, SH Jung, CM Hong, SY Han, JW Lee, HW Zee, OP Lee, KR
Citation
Hc. Kwon et al., Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica, ARCH PH RES, 22(4), 1999, pp. 410-413
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
22
Issue
4
Year of publication
1999
Pages
410 - 413
Database
ISI
SICI code
0253-6269(199908)22:4<410:INOSIF>2.0.ZU;2-3
Abstract
In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibi tory compounds from higher plants of South Korea, two beta-carboline alkalo ids, 4-methoxy-1-vinyl-beta-carboline (1) and 4,8-dimethoxy-1-vinyl-beta-ca rboline (2) have been isolated from the cortex of Melia azedarach var. japo nica. The structures of these compounds were elucidated on the basis of spe ctroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNO S on LPS- and interferon-gamma-stimulated RAW 264.7 cells.