The target article approaches individual differences in terms of phenotypic
differences developing through the interaction between a specific genetic
make up and environmental variables. This interaction is proposed to be coo
perative and oriented toward a progressive stabilisation of the trait. Howe
ver, experimental data from animal studies indicate that environmental pres
sure promotes dramatic changes in phenotypic expression in mature organisms
. Indeed, environmental constraint not only promotes the phenotypic express
ion of facilitated VTA-NAS DA transmission in genotype-resistant individual
s; it also inhibits its expression in genetically prone individuals. This i
s in line with negative genotype-environment correlation revealed by behavi
or genetics.