Depue & Collins's (D&C's) work relies on extrapolation from data obtained t
hrough studies in experimental animals, and needs support from studies of t
he role of dopamine (DA) neurotransmission in human behaviour. Were we revi
ew evidence from two sources: (1) studies of patients with Parkinson's dise
ase and (2) positron emission tomography (PET) studies of DA neurotransmiss
ion, which we believe lend support to Depue & Collins's theory, and which c
an potentially form the basis for a true neurochemistry of personality.