Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na+/glucose cotransporter (SGLT1): Recognition of sugar conjugates by SGLT1 is much less restricted than transport
T. Mizuma et al., Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na+/glucose cotransporter (SGLT1): Recognition of sugar conjugates by SGLT1 is much less restricted than transport, BIOL PHAR B, 22(8), 1999, pp. 876-879
Transport and recognition of aminopeptidase-resistant cellobiose-coupled ty
rosylglycylglycine (CcpTGG) by intestinal Na+/glucose cotransporter (SGLT1)
was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT
1 inhibitor) on the CcpTGG transport was extremely low: Concentration depen
dence of the CcpTGG transport was observed, but the primary component of tr
ansport was passive diffusion. However, CcpTGG significantly inhibited SGLT
1-mediated transport, indicating its recognition by SGLT1. Other glucose-co
njugates also inhibited SGLT1-mediated transport. These results indicate th
at recognition of sugar conjugates by SGLT1 is much less restricted than tr
ansport, and that it should be relatively easier to design SGLT1 inhibitors
than SGLT1-transportable sugar conjugates.