A novel class of inhibitors for human steroid 5 alpha-reductase: Phenoxybenzoic acid derivatives. I

In a search for novel nonsteroidal inhibitors of human prostatic 5 alpha-re ductase, we found a new series of phenoxybenzoic acid derivatives to be pot ent human prostatic 5 alpha-reductase inhibitors. Among them, 4-(biphenyl-4 -yloxy)benzoic acid derivatives (2n, YM-31758), 2o and 2s showed more poten t inhibitory activities than finasteride with IC50 values of 0.87, 0.67 and 0.56 nM, respectively. The optimized structures for the phenoxybenzoic aci d derivatives 2d-2i were calculated by molecular modeling analysis, and the favorable distance between the carbon of the carboxyl group and the centro id of the phenyl group (benzene ring C) was found to be in the 9-11 Angstro m range.