Reversible cerebral hypoperfusion observed with Tc-99m HMPAO SPECT in reversible dementia caused by hypothyroidism

Authors
Kinuya, S Michigishi, T Tonami, N Aburano, T Tsuji, S Hashimoto, T
Citation
S. Kinuya et al., Reversible cerebral hypoperfusion observed with Tc-99m HMPAO SPECT in reversible dementia caused by hypothyroidism, CLIN NUCL M, 24(9), 1999, pp. 666-668
Citations number
8
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
CLINICAL NUCLEAR MEDICINE
ISSN journal
03639762 → ACNP
Volume
24
Issue
9
Year of publication
1999
Pages
666 - 668
Database
ISI
SICI code
0363-9762(199909)24:9<666:RCHOWT>2.0.ZU;2-K
Abstract
A 69-year-old man had hypothyroid dementia as a result of I-131 therapy and an overdose of methimazole. Tc-99m HMPAO SPECT revealed diffuse cerebral h ypoperfusion. The findings of brain SPECT normalized with the disappearance of symptoms and a return to the euthyroid state. There was a 25% or 26% re duction of the mean cerebral blood flow during dementia. This may be the fi rst report in which SPECT brain imaging revealed reversible hypoperfusion a ssociated with reversible hypothyroid dementia.