Bl. Erstad, Pharmacoeconomic comparison of an albumin-furosemide complex versus sequential therapy for renal insufficiency, CLIN THER, 21(8), 1999, pp. 1380-1386
The purpose of this economic analysis was to develop an economic model usin
g intra-institutional cost data for acute, oliguric renal insufficiency tre
ated with either an albumin-furosemide complex or albumin followed by furos
emide (sequential therapy). The perspective of this study was from the stan
dpoint of the institution (University Medical Center, a teaching hospital).
The decision tree and sensitivity analyses demonstrated that the albumin-f
urosemide complex would be more effective and less costly than sequential t
herapy for a range of outcome probabilities. Using effectiveness assumption
s from published literature, the complex could avoid dialysis in 27% of pat
ients compared with 8% of patients receiving sequential therapy. The comple
x would also be less costly ($7778 vs $8748). In terms of cost-effectivenes
s, the complex is $28,807 per averted dialysis compared with $109,350 for s
equential therapy.