MULTICORE MYOPATHY - REPORT OF 5 CASES

Five cases (three of them from a same family) of multicore myopathy ar e presented, The age at diagnosis ranged from 4 to 38 years, In 2 case s muscle complaints develope early in chidhood while in the remaining 3 cases raised CK serum levels lead to perform a muscle biopsy. Malign ant hyperthermia occurred in a young boy among the three affected rela tives. Other family members are probably affected, suggesting an autos omal dominant inheritance. In none of the patients progressive disabli ng myopathy has occurred after a long term follow-up. A review of the bibliography is included, and clinical and evolutive characteristics o f this myopathy are commented.