Effect of bradykinin and its antagonist on survival time after coronary artery occlusion in rats

The present study was conducted to examine the effect of bradykinin and bra dykinin 2 receptor antagonist on survival time in rats with coronary artery ligation for 15 min and continuously. We also evaluated the heart rate and blood pressure responses in the presence and absence of bradykinin and its antagonist. Bradykinin treatment (4 mu g and 8 mu g/kg IV) significantly ( p < 0.05) increased the survival time of rats compared with saline-treated rats with coronary artery ligation for 15 min and continuously. The heart r ate and blood pressure responses were significantly (p < 0.001) altered in the presence of coronary artery ligation. Bradykinin antagonist treatment ( 4 mu g/kg IV) abolished the effect of bradykinin and thus reduced the survi val time of rats with coronary artery ligation. The mean value of survival time between saline-treated and bradykinin antagonist- plus bradykinin-trea ted rats did not differ significantly (p > 0.05). (C) 1999 Elsevier Science Inc. All rights reserved.