A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16

Authors
Thomson, SAM Rasmussen, SA Zhang, J Wallace, MR
Citation
Sam. Thomson et al., A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16, HUM GENET, 105(1-2), 1999, pp. 171-173
Citations number
9
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN GENETICS
ISSN journal
03406717 → ACNP
Volume
105
Issue
1-2
Year of publication
1999
Pages
171 - 173
Database
ISI
SICI code
0340-6717(199907/08)105:1-2<171:ANHCFA>2.0.ZU;2-H
Abstract
Hereditary cylindromatosis (HC; MIM 132700) is an autosomal dominant condit ion characterized by benign skin appendage tumors most commonly on the scal p and face. Previously, the HC gene (CYLD1) was linked to chromosome 16q12- 13, and tumors showed loss of heterozygosity (LOH), suggesting that CYLD1 i s a tumor suppressor gene. Here we report a new multi-generation cylindroma tosis family whose condition maps to that region, with 7/13 tumors showing LOH on 16q.