Imaging of current density and current pathways in rabbit brain during transcranial electrostimulation

A magnetic resonance imaging (MRI) method was used for a noninvasive study of current density (CD) and current pathways (CP's) inside the skull during transcranial electrostimulation in rabbits. The transcranial impulse curre nt directions studied were those previously used in transcranial electric t reatment either sagittally or bilaterally. MRI data were collected from sli ces perpendicular to the direction of current application. In these slices, only the perpendicular component of the CD was measured. Computer methods for accurate topographic mapping of the main areas with high CD and for rec onstruction of CP's are described. It was revealed that current applied on the head sagittally passed mostly t hrough the cerebrospinal fluid in the basal brain cisternas connected in se ries, and through the anterior horns of the lateral ventricles, foramina of Monro, ventrocaudal part of the third ventricle, aqueductus, and fourth ve ntricle. Possible connections between these CP's are suggested. Bilaterally applied current passed through the brain and skull core more diffusely wit hout concentrations in cisternas and ventricles. The results of the present study suggest an explanation for the observation that sagittally applied c urrent more effectively stimulates brain structures with antinociceptive fu nction and elicits more pronounced analgesic effect.