DEVELOPMENT AND STUDY OF IMMUNOGLOBULIN T O LASSA FEVER VIRUS

The authors validate the use of horses as producers of immune antiseru m to Lassa virus. Specific immunoglobulin with at least 1:512 titer of virus neutralizing antibodies to Lassa virus was obtained from the se rum of immunized horses by Kohn's alcohol method. The resultant prepar ation does not differ from the heterologous commercial immunoglobulins . Preclinical studies of immunoglobulin against Lassa virus demonstrat ed its safety and high specific activity. The strategy of treating wit h the immunoglobulin alone and in combination with virasol has been ex perimentally validated.