USE OF THE CATALYTIC CHARACTERISTICS OF I RON-CONTAINING SOLS IN IMMUNOASSAY

The possibility of using inorganic catalysts as markers for solid-phas e immunoassay on the plates is shown with iron-containing hydrosols: f errum hydroxide, ammonium ferriglycerate, and ferrum hydroxide modifie d with potassium ferrocyanide. Diagnostic agents based on iron-contain ing sols with dispersion of 0.5 to 0.8 mm bound to immunoglobulins or staphylococcal protein A are no less sensitive Chan the immunoperoxida se agents, provided the same developing system is used (o-phenylenedia mine + hydrogen peroxide). The sensitivity of solid-phase immunocataly tical assay of purified vaccinia and Venezuelan equine encephalomyelit is virus antigens was about 2 and 10 ng/ml, respectively. Hence, inorg anic catalysts are prospective markers for immunoassay.