Haloperidol increases spreading and nitric oxide production in macrophagesfrom tumor-bearing mice: a possible mechanism for its antitumoral effect

Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase b oth the percent of macrophage spreading and nitric oxide (NO) release in pe ritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10 (6) Ehrlich ascites cells. This haloperidol-induced macrophage activation s eems to be involved in its antitumoral effect since cotreatment with the iN OS inhibitor aminoguanidine was able to reverse the inhibitory effect of ha loperidol on the development of the Ehrlich solid carcinoma. (C) 1999 Inter national Society for Immunopharmacology, Published by Elsevier Science Ltd. All rights reserved.