Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chainisolated from myxobacteria - Production, isolation, physico-chemical and biological properties
F. Sasse et al., Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chainisolated from myxobacteria - Production, isolation, physico-chemical and biological properties, J ANTIBIOT, 52(8), 1999, pp. 721-729
New antibiotic compounds, melithiazols, were isolated from the culture brot
h of strains of the myxobacteria Melittangium lichenicola, Archangium gephy
ra, and Myxococcus stipitatus. The compounds belong to the group of beta-me
thoxyacrylate (MOA) inhibitors and are related to the myxothiazols. The mel
ithiazols show high antifungal activity, but are less toxic than myxothiazo
l A and its methyl ester in a growth inhibition assay with mouse cell cultu
res. The melithiazols inhibit NADH oxidation by submitochondrial particles
from beef heart. Melithiazol A blocks the electron transport within the bc(
1)-segment (complex III) and causes a red shift in the reduced spectrum of
cytochrome b.