Chiral separations by open tubular capillary electrokinetic chromatography

The inner walls of 50 mu m fused-silica capillaries are etched by ammonium hydrogendifluoride and then modified by the silanization/hydrosilation meth od with a chiral selector. Three different types of selectors were evaluate d: lactone, beta-cyclodexhin and naphthylethylamine. Each of the bonded chi ral stationary phases provided at least partial separation for one type of racemic solute. These results confirm that bonded organic moieties on the e tched inner wall of a capillary can provided sufficient solute-bonded phase interactions to influence the retention of molecules driven through a capi llary by electroosmosis or a combination of electroosmosis and electrophore tic mobility. (C) 1999 Elsevier Science B.V. All rights reserved.