The inner walls of 50 mu m fused-silica capillaries are etched by ammonium
hydrogendifluoride and then modified by the silanization/hydrosilation meth
od with a chiral selector. Three different types of selectors were evaluate
d: lactone, beta-cyclodexhin and naphthylethylamine. Each of the bonded chi
ral stationary phases provided at least partial separation for one type of
racemic solute. These results confirm that bonded organic moieties on the e
tched inner wall of a capillary can provided sufficient solute-bonded phase
interactions to influence the retention of molecules driven through a capi
llary by electroosmosis or a combination of electroosmosis and electrophore
tic mobility. (C) 1999 Elsevier Science B.V. All rights reserved.